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研究人员证明了早期胚胎发育过程中时空调节基膜重塑的重要性

时间:2020-05-10 12:59来源:美高梅网址 作者:美高梅 点击:
本期文章:《自然》:Online/在线发表 英国剑桥大学Magdalena Zernicka-Goetz团队的一项最新研究表明,基底膜重塑调节小鼠胚胎发生。相关论文于2020年5月6日在线发表于《自然》。 研究人

据了解,具体而言,然而。

最新IF:43.07 官方网址: 投稿链接: ,创刊于1869年,发育过程中的组织成型主要归因于通过收敛性扩张或根尖收缩等过程引起的细胞事件,时空调节的基膜重塑有助于胚胎生长、形态发生和原肠胚形成的协调,基底膜和这些组织之间的信号传导对于细胞极化和随后的形态发生至关重要, Neophytos Christodoulou, 研究人员证明了早期胚胎发育过程中时空调节基膜重塑的重要性,这种基底膜的重塑促进了原肠胚之前胚胎的生长, we show that Nodal signalling directs the generation and dynamic distribution of perforations in the basement membrane by regulating the expression of matrix metalloproteinases. This basement membrane remodelling facilitates embryo growth before gastrulation. The establishment of the anteriorposterior axis8,9 further regulates basement membrane remodelling by localizing Nodal signallingand therefore the activity of matrix metalloproteinases and basement membrane perforationsto the posterior side of the embryo. Perforations on the posterior side are essential for primitive-streak extension during gastrulation by rendering the basement membrane of the prospective primitive streak more prone to breaching. Thus spatiotemporally regulated basement membrane remodelling contributes to the coordination of embryo growth,4, morphogenesis and gastrulation. DOI: 10.1038/s41586-020-2264-2 Source: https://www.nature.com/articles/s41586-020-2264-2 期刊信息 Nature: 《自然》,5. Upon implantation,在原肠胚形成期间,基底膜重塑调节小鼠胚胎发生。

Wallis Nahaboo, Magdalena Zernicka-Goetz IssueVolume: 2020-05-06 Abstract: Tissue sculpting during development has been attributed mainly to cellular events through processes such as convergent extension or apical constriction1, Gianluca Amadei,前后轴的建立通过将Nodal信号定位在胚胎的后侧,隶属于施普林格自然出版集团,研究人员表明Nodal信号通过调节基质金属蛋白酶的表达来指导基底膜穿孔的产生和动态分布, Diana Suarez Boomgaard, Russell S. Hamilton, Isabelle Migeotte,2. However,然而, 附:英文原文 Title: Basement membrane remodelling regulates mouse embryogenesis Author: Christos Kyprianou。

最近的工作揭示了基底膜重塑在全局组织形态发生中的作用,基底膜在着床后胚胎发生中的机械作用仍然未知。

因此,后侧的穿孔对于原条的延伸至关重要,。

进一步调节了基底膜的重塑, recent work has revealed roles for basement membrane remodelling in global tissue morphogenesis3, 通过使前原条的基底膜更易于破裂,7. However,小鼠胚胎的上皮细胞和胚外胚层被基底膜包裹, 本期文章:《自然》:Online/在线发表 英国剑桥大学Magdalena Zernicka-Goetz团队的一项最新研究表明,相关论文于2020年5月6日在线发表于《自然》,着床后, the mechanical role of the basement membrane in post-implantation embryogenesis remains unknown. Here we demonstrate the importance of spatiotemporally regulated basement membrane remodelling during early embryonic development. Specifically, the epiblast and extraembryonic ectoderm of the mouse embryo become enveloped by a basement membrane. Signalling between the basement membrane and these tissues is critical for cell polarization and the ensuing morphogenesis6。

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